Isoxsuprine Hcl

Vasodilator used historically in horses for navicular disease (caudal heel syndrome); promotes digital vasodilatation. Vasodilator with beta-adrenergic agonist properties (isoxsuprine HCl). Mechanism: beta-2 adrenergic receptor activation → vascular smooth muscle relaxation → peripheral and digital vasodilation; also inhibits platelet aggregation. Primarily used in horses for navicular disease to increase digital blood flow. Oral or IM administration. Key information Vasodilator — used for navicular disease in horses. Oral only. Administer on empty stomach for best absorption. Long-term therapy often required. Store at room temperature.

Oral tablets (horses): administer orally mixed into grain or via dose syringe. Administer with food to reduce GI adverse effects. Administer twice daily at consistent times. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Administer on empty stomach for best absorption.

Cardiovascular: tachycardia, palpitations, hypotension. GI: nausea, vomiting. CNS: dizziness, restlessness. Sweating. Tremors. Horses: generally well tolerated at labeled doses; tachycardia most common adverse effect.

For animals Use with caution in patients with tachycardia or cardiovascular disease. Not approved for use in food-producing animals. Evidence for efficacy in navicular disease is limited. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Vasodilator — Wash hands thoroughly with soap and water after handling. after handling tablets. Keep out of reach of children. May cause flushing if ingested.

Contact your veterinarian. Isoxsuprine overdose causes low blood pressure, rapid heart rate, and GI signs.