Itraconazole Powder

Triazole antifungal for systemic fungal infections (aspergillosis, candidiasis, histoplasmosis, blastomycosis) in horses and small animals; guttural pouch mycosis in horses. Triazole antifungal (itraconazole). Mechanism: inhibits fungal CYP51 (lanosterol 14α-demethylase) → blocks ergosterol biosynthesis → membrane permeability disruption. Lipophilic; high tissue penetration (concentrated in keratin, lung, liver) but poor CSF penetration. Metabolized via CYP3A4. Active against Aspergillus, Histoplasma, Blastomyces, dermatophytes. Fungistatic. Key information Refrigerate oral suspension; shake well. Capsules: administer with food (absorption requires acid environment). Significant drug interactions (potent CYP3A4 inhibitor). Monitor hepatic function. Check formulation — solution vs capsule bioavailability differs. Compounded powder: verify stability.

Oral capsules: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. (fatty meal enhances absorption for capsule form). Oral solution: administer on an empty stomach. Do not substitute formulations without dose adjustment. Store at room temperature; protect from light. (capsules); Store refrigerated (2–8°C); do not freeze. (solution — once opened). If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Administer with food. Complete the full course — antifungal therapy is typically prolonged.

GI: vomiting, diarrhea, anorexia (common). Hepatotoxicity (monitor liver enzymes — sometimes fatal). Negative inotropic effect (cardiac toxicity — especially with IV formulation — avoid in CHF). Adrenal suppression (weak inhibition of cortisol synthesis). Hypokalemia, hypertension (edema). Numerous CYP3A4 drug interactions. Skin: rash, pruritus.

For animals Monitor liver enzymes with prolonged use. — monitor liver enzymes monthly. Avoid in patients with CHF or pre-existing cardiac disease. Numerous drug interactions (CYP3A4 inhibitor): increases cyclosporine, digoxin, and many other drug levels. Avoid in pregnant animals. Drug-drug interaction: rifampin markedly reduces itraconazole levels. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Triazole antifungal — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Teratogenic. Keep out of reach of children.

Contact your veterinarian. Overdose causes GI signs and liver toxicity. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.