Ketofen

Ketoprofen NSAID for musculoskeletal pain, fever, and inflammation in horses; also used in dogs and cats. Propionic acid NSAID (ketoprofen). Mechanism: non-selective COX-1 and COX-2 inhibitor → reduces prostaglandin synthesis. Also inhibits lipoxygenase (LOX) pathway → reduced leukotriene production (dual COX/LOX inhibitor). Available as injectable and oral formulations. Approved for horses and cattle in some countries. Key information Ketoprofen — NSAID. Do not use in horses intended for human consumption. IV or IM. Avoid concurrent NSAIDs or corticosteroids. GI ulceration risk. Store at room temperature.

Injectable: administer IV or IM as directed. IV: inject slowly. Oral: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

GI: vomiting, diarrhea, gastric/intestinal ulceration. Renal: azotemia. Hepatotoxicity. Hematologic: platelet inhibition. Do not combine with other NSAIDs or corticosteroids.

For animals Monitor for GI ulceration; use with caution in animals with GI disease. Monitor renal function, hydration status, and urine output. Do not use concurrently with other NSAIDs or corticosteroids. Monitor liver enzymes with prolonged use. Observe food animal withdrawal times for milk and meat. for food animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). NSAID — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.

Contact your veterinarian immediately. Ketoprofen overdose causes GI ulceration and kidney injury. IV supportive care required.