Ketorolac Tromethamine

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General Drug Information and Indications

NSAID ophthalmic drops for anterior uveitis, post-operative ocular inflammation, and miosis inhibition during surgery. Non-selective NSAID ophthalmic solution (ketorolac tromethamine). Mechanism: inhibits COX-1 and COX-2 in ocular tissues → reduces prostaglandin-mediated inflammation, miosis, and vascular permeability. Available as 0.5% ophthalmic solution. Systemic absorption minimal with topical ophthalmic use. Key information NSAID — short-term use only (5 days maximum). Ophthalmic formulation for veterinary use. Systemic absorption from ophthalmic route possible. Do not use in animals with bleeding disorders.

How to Give this Medication

Ophthalmic solution: Instill into the conjunctival sac; avoid touching dropper tip to eye or periocular tissue. Instill 1 drop into affected eye(s) as directed. Store at room temperature; protect from light. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Side Effects

Ophthalmic: transient stinging, burning upon instillation. Mild superficial punctate keratopathy. Delays corneal epithelial wound healing at high doses (COX inhibition). Systemic absorption minimal with topical use.

Precautions

For animals Topical ophthalmic — assess corneal integrity before use. May slow corneal epithelial healing. Do not use concurrently with other NSAIDs or corticosteroids. for systemic NSAIDs concurrently. For people handling this medication Wash hands thoroughly with soap and water after handling. Ophthalmic NSAID — avoid human eye contact. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Wash hands thoroughly with soap and water after handling. Keep out of reach of children.

Overdose

Contact your veterinarian if excessive product was instilled. Ophthalmic NSAID — systemic toxicity from eye drops is unlikely but contact vet if animal shows GI signs.

Ketorolac Tromethamine dosage forms

ProductStrengthFormSizeType
KETOROLAC TROMETHAMINE 0.5% OPH SOLN—Solution1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual – Nonsteroidal Anti-inflammatory Drugs in Animals (https://www.merckvetmanual.com/pharmacology/inflammation/nonsteroidal-anti-inflammatory-drugs-in-animals); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)