L-arginine

Amino acid precursor to nitric oxide; endothelial and vascular health supplementation in horses. Conditionally essential amino acid. Mechanism: precursor to nitric oxide (NO) via nitric oxide synthase (NOS) → NO causes vascular smooth muscle relaxation → vasodilation and improved endothelial function. Also substrate for polyamine synthesis, creatine, and urea cycle. Supplementation supports immune function and wound healing. Key information Amino acid supplement. Store at room temperature. Generally safe. May affect nitric oxide production. Not a substitute for veterinary treatment.

Oral supplement: mix into feed or food. Administer with food to reduce GI adverse effects. Administer as directed for specific indication. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If you forget a day, simply resume the normal schedule the next day. Missing an occasional dose of this supplement is unlikely to cause harm.

Generally well tolerated at supplemental doses. GI: nausea, vomiting, diarrhea (high doses). Hypotension (vasodilation). Hyperkalemia (rare). Allergic reactions (rare). Caution in herpes infections (arginine may promote viral replication).

For animals Use with caution in patients with herpesvirus infections — arginine may promote viral replication. Monitor blood pressure (vasodilatory effects). For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Amino acid supplement — generally safe. Wash hands thoroughly with soap and water after handling.

Overdose with this supplement is unlikely to cause serious harm at slightly elevated doses, but contact your veterinarian if a large excess was given or if your animal shows any unusual signs. L-arginine overdose may cause GI signs. Contact your veterinarian if large excess was given.