Labetalol Tab

Combined alpha/beta-adrenergic blocker for hypertensive crises in dogs; tachyarrhythmias. Non-selective alpha-1 and beta (beta-1, beta-2) adrenergic receptor antagonist. Mechanism: combined blockade reduces peripheral vascular resistance (alpha-1) and heart rate/contractility (beta) → antihypertensive effect without reflex tachycardia. 1:3 alpha:beta ratio after IV administration. Hepatically metabolized. Key information Combined alpha-/beta-blocker. Store at room temperature. Do not discontinue abruptly. Monitor heart rate and blood pressure.

IV: administer slow IV bolus over 2 min or as CRI; monitor BP and ECG continuously. Oral: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose. Never abruptly stop this medication.

Hypotension, bradycardia, AV block. Bronchospasm (beta-2 blockade — avoid in asthma/RAO). Lethargy, depression. GI: nausea, vomiting. Orthostatic hypotension.

For animals Avoid in AV block, decompensated heart failure, bronchospasm. Monitor blood pressure and heart rate. Reduce dose or extend interval in renal impairment. Use with caution in hepatic impairment. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Alpha/beta blocker — keep out of reach of children. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian or emergency clinic immediately. Beta-blocker overdose causes bradycardia, low blood pressure, and bronchospasm.