Latanoprost

Prostaglandin F2α analogue ophthalmic drops for reduction of intraocular pressure in glaucoma in dogs and horses. Prostaglandin F2α analogue (latanoprost 0.005% ophthalmic solution). Mechanism: prodrug — hydrolyzed to active latanoprost acid by corneal esterases → binds FP prostaglandin receptors → increases uveoscleral (unconventional) aqueous humor outflow → reduces IOP. Once-daily dosing (evening preferred). May cause iris pigmentation change (brown iris). Key information Prostaglandin F2α ophthalmic analogue for glaucoma. Refrigerate unopened; store open vial at room temperature ≤6 weeks. For ophthalmic use only. May cause iris hyperpigmentation with long-term use. Miosis expected.

Ophthalmic solution: Instill into the conjunctival sac; avoid touching dropper tip to eye or periocular tissue. Instill 1 drop into affected eye(s) once daily (typically in the evening). Store refrigerated (2–8°C); do not freeze. (unopened); once opened, may store at room temperature for 6 weeks. Use punctal occlusion to reduce systemic absorption. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Ophthalmic: conjunctival hyperemia, ocular irritation, burning/stinging. Iris color change (increased brown pigmentation — irreversible, especially in heterochromic eyes). Increased eyelash growth, darkening. Uveitis (uncommon). Systemic: bronchospasm (prostaglandin — caution in asthma). Macular edema (rare). Cystoid macular edema.

For animals Ophthalmic prostaglandin — causes miosis (contraindicated as only IOP medication in patients requiring mydriasis for examination). Iris color change possible (irreversible in heterochromic eyes). Uveitis: use with caution in patients with concurrent intraocular inflammation. Avoid in pregnant animals. — PGF2α analogue. For people handling this medication Wash hands thoroughly with soap and water after handling. Ophthalmic prostaglandin — avoid human eye contact (may change iris color irreversibly). Refrigerate; keep out of reach of children. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Prostaglandin — avoid exposure if pregnant.

Contact your veterinarian. Excess prostaglandin ophthalmic drops may cause increased miosis and irritation. Systemic effects are unlikely with topical overdose.