Legend Ia

Hyaluronic acid (hyaluronan) IV or intra-articular injection for equine joint disorders; synovitis, capsulitis, and osteoarthritis. Sodium hyaluronate IV injection (equine hyaluronate). Mechanism: high-molecular-weight (MW ~730 kDa) HA administered IV distributes to synovial fluid compartments → reduces synovial inflammation; stimulates endogenous HA production by synoviocytes via CD44 receptor signaling; anti-inflammatory via free radical scavenging. IV route enables multi-joint treatment. FDA-approved for horses. Key information Hyaluronan (hyaluronic acid) — IV or intra-articular for horses. Refrigerate. Use sterile technique for IA injection. IV administration for systemic joint benefit. Single-use vial.

IV injection (horses): administer as slow IV injection over 1–2 min. Have epinephrine available for anaphylactic reactions. Horses should be standing and monitored. Intra-articular: aseptic technique; aspirate joint fluid before injection. Post-IV rest: 24 hrs. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

IV injection: transient swelling, mild phlebitis at injection site. Mild transient facial swelling/head tossing (rare reaction). Intra-articular: post-injection synovitis (24–72 hrs). Generally very well tolerated with IV administration in horses.

For animals IV administration only (horses). Administer slowly. Monitor for anaphylactic-type reactions. Post-injection rest: 24 hrs light work. Not for use in infected joints. For people handling this medication Administered by veterinary professionals only. No specific human precautions for caregivers beyond normal hygiene.

Contact your veterinarian. Sodium hyaluronate joint injection — overdose may cause transient joint effusion and inflammation. Managed by veterinary staff.