Levetiraceta Tab

Anticonvulsant for epilepsy and seizures in dogs, cats, and horses; broad-spectrum with minimal hepatic metabolism. Second-generation anticonvulsant (levetiracetam). Mechanism: binds synaptic vesicle glycoprotein SV2A → modulates presynaptic vesicle function and neurotransmitter release → reduces abnormal neuronal synchronization. Novel mechanism distinct from sodium channel or GABA-A modulators. Renally excreted unchanged; no hepatic metabolism → minimal drug interactions. Key information Levetiracetam — see levetiracetam entry. Do not crush extended-release tablets. Fewer drug interactions than phenobarbital.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or without. Do not crush extended-release formulations. Administer at consistent times to maintain stable blood levels. Oral solution: measure carefully. IV (extra-label): dilute in 0.9% NaCl; infuse over 15–30 min. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Do not abruptly discontinue.

CNS: sedation, ataxia, behavioral changes (aggression, anxiety — especially in cats). GI: vomiting, anorexia (uncommon). Generally well tolerated compared to older anticonvulsants. Abrupt discontinuation may precipitate seizures.

For animals Reduce dose or extend interval in renal impairment. — dose-reduce in renal impairment (renally cleared unchanged). Abrupt discontinuation: risk of breakthrough seizures — taper gradually. Generally fewer drug interactions than older anticonvulsants. Behavioral changes (especially in cats) at high doses — reduce dose if noted. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Anticonvulsant — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.

Contact your veterinarian. Overdose causes sedation and GI signs. Supportive care as needed.