Losartan Pot Tab

Angiotensin II receptor blocker for hypertension and renal protection in dogs (extralabel); alternative to ACE inhibitors. Angiotensin II receptor blocker (ARB — losartan potassium). Mechanism: selective competitive antagonist of AT1 angiotensin II receptors → vasodilation, reduced aldosterone secretion, decreased renal tubular sodium reabsorption → antihypertensive. Unlike ACE inhibitors, does not prevent angiotensin II formation via non-ACE pathways and does not cause bradykinin accumulation (no cough). Prodrug; active metabolite EXP3174. Key information Angiotensin II receptor blocker (ARB). Store at room temperature. Monitor renal function and potassium. Avoid in pregnant animals (fetotoxic). Alternative to ACE inhibitors.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or without. Tablets may be crushed. Administer at consistent times. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose.

Hypotension (first-dose effect, concurrent diuretics). Azotemia/renal impairment (RAAS blockade). Hyperkalemia. GI: diarrhea, nausea. Angioedema (rare — less than ACE inhibitors in humans). No dry cough (unlike ACE inhibitors).

For animals Reduce dose or extend interval in renal impairment. Avoid in pregnant animals. Monitor potassium (hyperkalemia risk with concurrent potassium-sparing diuretics). Monitor blood pressure. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). ARB antihypertensive — keep out of reach of children. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Contraindicated in human pregnancy.

Contact your veterinarian. ARB overdose causes low blood pressure. Signs include weakness and collapse. IV fluid support may be needed.