Lutalyse

Dinoprost tromethamine (natural PGF2α) for luteolysis, estrus synchronization, pregnancy termination, and pyometra in horses, cattle, and swine. Natural prostaglandin F2α (dinoprost tromethamine). Mechanism: binds FP receptors on corpus luteum → luteolysis via increased prostaglandin and decreased progesterone synthesis; also stimulates uterine smooth muscle contraction (oxytocic). Shorter duration than synthetic analogues. Available as 5 mg/mL injectable solution. Key information Dinoprost tromethamine — prostaglandin F2α. HUMAN SAFETY: Bronchospasm and uterine contractions — do NOT handle if pregnant or asthmatic. Wear gloves and eye protection. Self-injection: emergency — flush immediately, seek medical attention. Refrigerate.

IM injection: administer deep IM into large muscle mass. NEVER administer IV. Wear chemical-resistant gloves throughout. Horses: administer in neck or gluteals; observe for 60 min post-injection. Cattle: neck or gluteal IM injection as labeled. Have bronchodilator available for horses if adverse respiratory reaction occurs. Store at room temperature; protect from light. If a dose is missed This product is given as a single dose or as part of a defined protocol. Contact your veterinarian if a scheduled administration was missed. Lutalyse is used in reproductive protocols — contact your veterinarian.

GI: diarrhea, abdominal cramping. Sweating, restlessness, tachycardia, bronchospasm (transient — within 1 hr, horses). Abortion in any pregnant animal — use with caution. IV injection: severe cardiovascular reactions, bronchospasm, potentially fatal — IM or SQ route only. Human: dangerous with skin exposure (pregnant women, cardiovascular/respiratory disease).

For animals Causes luteolysis — Avoid in pregnant animals. will induce abortion in all pregnant animals. Do not administer IV to horses (severe anaphylactoid reactions — IM/SQ only). Confirm corpus luteum presence before use for luteolysis. Monitor horses for 1 hr post-administration for adverse reactions. For people handling this medication SERIOUS HUMAN HAZARD: Dinoprost (PGF2α) is rapidly absorbed through skin and can cause bronchospasm, uterine contractions, and serious cardiovascular effects. Pregnant women and women of childbearing age (or individuals with asthma) must NOT handle this product — can induce abortion or premature labor. Wear chemical-resistant (nitrile) gloves and protective clothing covering all skin. Avoid all skin and eye contact. If skin contact occurs, wash immediately with soap and water. If eye contact occurs, flush with water for 15+ minutes and seek medical attention immediately. Keep out of reach of children.

Contact your veterinarian. Prostaglandin overdose causes uterine cramping and cardiovascular effects. Human exposure requires immediate medical attention.