Marquis

Oral ponazuril (anticoccidial) for treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona. Anticoccidial triazinetrione antiprotozoal (ponazuril). Mechanism: targets the apicoplast organelle of apicomplexan parasites (Sarcocystis neurona) → disrupts folic acid metabolism, organelle division, and parasite replication. Active against multiple life cycle stages. Oral paste for horses. Key information Ponazuril — antiprotozoal for EPM in horses. Paste form. Store at room temperature. Administer once daily x 28 days. May be crushed/mixed with feed.

Oral paste (ponazuril, horses): administer via dose syringe into the back of the mouth. Once daily for 28 days. Administer at the same time each day. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Continue the full 28-day course.

Generally well tolerated at labeled doses. GI: loose feces, mild diarrhea (transient). Horses: no significant systemic toxicity at therapeutic doses.

For animals Horses only — not for use in other species at equine doses. Not approved for use in food-producing animals. Administer full course (28 days) even if improvement noted early. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Antiprotozoal paste — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. Ponazuril overdose is generally mild.