Methocarbamol Tablets

Centrally-acting skeletal muscle relaxant (methocarbamol) for muscle spasm and ataxia in horses and small animals; tetanus adjunct. Centrally-acting skeletal muscle relaxant (methocarbamol). Mechanism: acts at the level of the spinal cord interneurons to inhibit polysynaptic neural reflexes involved in muscle spasm → generalized muscle relaxation. Does not directly affect neuromuscular junction or skeletal muscle. Hepatically glucuronidated; urinary excretion. Key information Methocarbamol — see methocarbamol entry. Store at room temperature. IV: do not exceed 3 mL/min. May cause hemolysis with rapid IV.

IV: dilute in 0.9% NaCl or sterile water; Administer IV slowly; rapid infusion may cause adverse reactions. (do not exceed 2 mL/min IV) to avoid cardiovascular depression. IM: inject deep IM — limit volume per site. Oral: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

CNS sedation, ataxia, weakness (dose-dependent). GI: nausea, vomiting. IV: hypotension, cardiovascular depression (polyethylene glycol vehicle in injectable formulation — give slowly). Urine discoloration (green/brown — expected). Hepatic/renal dysfunction with prolonged use.

For animals IV: administer slowly (polyethylene glycol vehicle — cardiovascular depression). Reduce dose or extend interval in renal impairment. Use with caution in hepatic impairment. Urine discoloration (green/brown) expected — inform owners. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Muscle relaxant — may cause drowsiness if accidentally ingested. Wash hands thoroughly with soap and water after handling. Keep out of reach of children.

Contact your veterinarian. Methocarbamol overdose causes sedation and weakness. Supportive care required.