Metoclopramide Inj

Prokinetic and antiemetic for vomiting, gastric motility disorders, and GI stasis. Prokinetic and antiemetic (metoclopramide). Mechanism: D2 receptor antagonist in CTZ (antiemetic) and GI enteric nervous system (prokinetic). Also 5-HT4 receptor agonist augmenting acetylcholine release → increased gastric emptying and small intestinal motility. May cause extrapyramidal effects (tardive dyskinesia) with chronic use. Key information Do NOT use in animals with GI obstruction or hemorrhage. Extrapyramidal signs possible at high doses — agitation, disorientation. Increases gastric emptying — give 30 min before meals. Do not mix IV with bicarbonate.

Oral: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer 30 min before feeding. IV: dilute and infuse over 15–30 min or by CRI. SQ: administer SQ. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

Extrapyramidal effects: muscle tremors, restlessness, facial grimacing, disorientation (especially at high doses or prolonged use). Sedation. Diarrhea. Cats: may cause behavioral changes, agitation.

For animals Contraindicated with GI obstruction or perforation. Monitor for extrapyramidal signs. Not approved for use in food-producing animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Dopamine antagonist — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.

Contact your veterinarian. Metoclopramide overdose causes extrapyramidal signs (agitation, muscle spasms, restlessness) and sedation. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.