Metronidazol Inj

Nitroimidazole antibiotic/antiprotozoal for anaerobic bacterial infections, Giardia, and Tritrichomonas in horses and small animals. Nitroimidazole antibiotic/antiprotozoal (metronidazole). Mechanism: enters anaerobic organisms → reduced to cytotoxic nitro-radical intermediates by ferredoxin/NADPH oxidoreductase → DNA strand breakage → cell death. Selective for organisms with anaerobic metabolism. Bactericidal against anaerobes; active against Giardia, Tritrichomonas, Entamoeba. Key information Metronidazole injection — see metronidazole entry. Infuse slowly over 30–60 min. Neurotoxicity at high doses.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. to reduce GI upset. Tablets may be crushed and mixed into food. IV: dilute in compatible solution; infuse over 30–60 min — do not rapid infuse. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

GI: nausea, vomiting, anorexia, metallic taste (most common). Neurological (high doses or prolonged use): ataxia, seizures, peripheral neuropathy, vestibular signs (head tilt, nystagmus) — neurotoxic syndrome; discontinue and usually reversible. Hepatotoxicity (rare). Possible teratogenicity — avoid in pregnancy.

For animals Avoid in patients with CNS disease or hepatic encephalopathy (CNS toxicity risk). Monitor for neurological signs (ataxia, nystagmus, head tilt) — discontinue if noted. Drug interaction: CYP450 inhibitor — increases phenobarbital, cyclosporine levels. Avoid in pregnant animals. — avoid during first two-thirds of pregnancy. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Potential carcinogen with prolonged exposure (Ames test positive). Wear gloves when crushing tablets. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Avoid during first trimester. Keep out of reach of children.

Contact your veterinarian immediately. Metronidazole overdose causes neurological signs — vomiting, vestibular signs, seizures. Supportive care required.