Mirtazapine Tab

Antidepressant and appetite stimulant for anorexia, weight loss, and nausea in dogs and cats. Tetracyclic antidepressant / appetite stimulant (mirtazapine). Mechanism: alpha-2 adrenergic receptor antagonist (increases NE and 5-HT release) + 5-HT2A/2C and 5-HT3 receptor antagonist → increased appetite via 5-HT2C and H1 blockade in hypothalamus. Antiemetic via 5-HT3 antagonism. Available as oral tablet and transdermal formulation (cats). Key information Appetite stimulant/antiemetic. Cats: 1.88 mg (quarter of 7.5 mg tablet) every 72 hours — use very small doses. Serotonin syndrome risk if combined with SSRIs or MAOIs. Transdermal compounded formulation available. Store at room temperature.

Oral tablets (dogs and cats): Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Tablets may be split for dose adjustment. Transdermal (Mirataz — cats): apply measured amount to inner pinna using gloved finger; alternate ears. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose. Cats: dose every 72 hours — do not give more frequently.

CNS sedation (antihistaminic effect — often desired for appetite stimulation). GI: vomiting (uncommon). Urinary retention (anticholinergic). Serotonin syndrome (with other serotonergic drugs — potentially fatal). Constipation. Cats: transient vocalization after transdermal application (fomepizole-like reaction).

For animals Transdermal (cats): rotate application sites. Drug interaction: avoid MAOIs (serotonin syndrome). Cats: monitor for vocalization and agitation after transdermal application. Use with caution in hepatic impairment. Reduce dose or extend interval in renal impairment. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Antidepressant — Wash hands thoroughly with soap and water after handling. after handling transdermal form (wear gloves for transdermal). Keep out of reach of children. Serotonin syndrome risk if ingested with serotonergic human medications.

Contact your veterinarian immediately. Mirtazapine overdose causes serotonin syndrome: agitation, hyperthermia, tremors, and rapid heart rate. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.