Naloxone Inj

Opioid antagonist for reversal of opioid-induced respiratory depression and toxicity in horses and small animals. Opioid receptor antagonist (naloxone HCl). Mechanism: competitive antagonist at mu, kappa, and delta opioid receptors → rapidly reverses opioid-induced CNS and respiratory depression. Pure antagonist (no agonist activity). Short half-life (45–90 min); may need redosing. IV onset within 2 min. Does not reverse benzodiazepine or other CNS depressant effects. Key information Opioid reversal agent. IV preferred for fastest action; IM or SQ if IV unavailable. Duration shorter than most opioids — repeat dosing may be needed. Precipitates acute withdrawal — use cautiously in opioid-dependent animals. Refrigerate.

IV: administer rapidly IV for opioid reversal. IM or SQ: if no IV access. Sublingual or intratracheal: if no peripheral access. May repeat every 2–3 min as needed. Monitor for re-narcotization (short half-life) — may require CRI or repeat boluses. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Reversal of opioid analgesia (abrupt pain return — manage post-reversal pain appropriately). Opioid withdrawal syndrome: agitation, tachycardia, vomiting, sweating. Pulmonary edema (rare, with rapid reversal of opioid depression in humans). Short half-life — renarcotization possible (re-dose if needed).

For animals Short half-life (45–90 min) — re-narcotization possible after reversal of long-acting opioids; repeat dosing or CRI may be required. Reversal of analgesia: pain returns abruptly — manage pain appropriately post-reversal. Does not reverse non-opioid CNS depressants. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Opioid antagonist — generally safe to handle. If accidentally injected (in opioid-dependent persons), will precipitate withdrawal. Keep out of reach of children.

Overdose is managed by veterinary staff in a clinical setting. If an error occurred during in-hospital treatment, the attending veterinary team will manage the response.