General Drug Information and Indications

NSAID for soft tissue and musculoskeletal pain management; anti-inflammatory and analgesic. Propionic acid NSAID (naproxen sodium). Mechanism: non-selective COX-1 and COX-2 inhibitor → reduces prostaglandin synthesis → anti-inflammatory, analgesic, antipyretic effects. Long plasma half-life in most species. Limited approved veterinary use; primarily extralabel. Key information NSAID. Not commonly used in veterinary medicine — significant GI toxicity risk. Do NOT use in cats. Use with caution in dogs. Monitor carefully.

How to Give this Medication

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Administer twice daily as directed. Horses: administer orally in grain. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

Side Effects

GI: gastric ulceration, vomiting, diarrhea, melena (significant GI risk). Renal: azotemia. Horses: GI ulceration, right dorsal colitis. Hepatotoxicity. Do not use in cats. Do not combine with other NSAIDs or corticosteroids.

Precautions

For animals Monitor for GI ulceration; use with caution in animals with GI disease. Monitor renal function, hydration status, and urine output. Do not use concurrently with other NSAIDs or corticosteroids. Do not use in cats. Long half-life — risk of accumulation. Horses: GI ulceration risk including right dorsal colitis. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). NSAID — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. (Avoid in late human pregnancy).

Overdose

Contact your veterinarian immediately. Naproxen overdose is serious — causes GI ulceration and acute kidney failure. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.

Naproxen Tab dosage forms

ProductStrengthFormSizeType
NAPROXEN TAB 500MG500 MGTablet1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual – Nonsteroidal Anti-inflammatory Drugs in Animals (https://www.merckvetmanual.com/pharmacology/inflammation/nonsteroidal-anti-inflammatory-drugs-in-animals); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)