Naxcel
General Drug Information and Indications
Extended-release ceftiofur crystalline free acid (CCFA) for equine respiratory disease and cattle/swine bacterial infections.
Extended-release ceftiofur crystalline free acid injectable. Mechanism: third-generation cephalosporin — binds PBPs → inhibits bacterial cell wall synthesis (bactericidal). CCFA slowly dissolves from injection site providing sustained therapeutic concentrations for 7–14 days. Labeled administration in ear pinnae (horses/cattle) or SQ in specific sites.
Key information
Ceftiofur sodium — injectable cephalosporin. Reconstitute with sterile water. Refrigerate reconstituted solution; use within 12 hours. Beef withdrawal: 3 days. Approved for respiratory, metritis, footrot treatment.
How to Give this Medication
SQ injection at base of ear (horses) or SQ/IM injection at appropriate site (cattle). Shake well before each use. vigorously before use. Maximum volume per injection site: 15 mL (horses). Single or two-dose protocol depending on indication. Store at room temperature; protect from light.
If a dose is missed
This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.
Side Effects
Injection site reactions: significant, painful swelling and tissue reaction at base of ear (prolonged mass/lump common). Hypersensitivity (penicillin cross-reactivity). GI: diarrhea. Withdrawal times required for food animals.
Precautions
For animals
See excede/ceftiofur. Observe food animal withdrawal times for milk and meat. Not for use in horses intended for human consumption. Significant injection site reaction expected.
For people handling this medication
Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Extended-release cephalosporin — inform doctor if beta-lactam allergic. Wear gloves. Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately.
Overdose
Contact your veterinarian. Injectable ceftiofur — dosing is typically managed by veterinary staff.
Naxcel dosage forms
| Product | Strength | Form | Size | Type |
|---|---|---|---|---|
| NAXCEL 1 GM INJECTABLE | 1 GM | Injectable | 1 | Commercial |
| NAXCEL 4 G INJECTABLE | 4 G | Injectable | 1 | Commercial |
Sources
This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)