Neomycin Tab

Aminoglycoside for oral/topical use; GI decontamination; topical wound/ophthalmic infections; hepatic encephalopathy adjunct. Aminoglycoside antibiotic (neomycin sulfate). Mechanism: 30S ribosomal subunit binding → mRNA misreading → bactericidal protein synthesis inhibition. Poorly absorbed orally (GI decontamination use); topical for wounds and ophthalmic infections. Ototoxic and nephrotoxic — systemic use limited. Active against gram-negative aerobic bacteria. Key information Oral neomycin — not systemically absorbed. GI decontamination use. Toxicity risk if mucosal integrity compromised.

Topical: Apply topically to affected area; wear gloves during application. Apply thin layer 2–3 times daily. Clean ear canal before instillation. Gently massage base of ear after application to distribute medication. (verify TM integrity). Oral (GI decontamination): Administer orally. May be given with food to improve compliance and reduce GI upset. Wear gloves when handling. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Complete the full course.

Systemic: nephrotoxicity, ototoxicity (if systemically absorbed). Topical: contact allergy/sensitization (common). GI (oral): minimal absorption; if used for GI decontamination: diarrhea, altered gut flora, malabsorption. Otic: ototoxicity if TM ruptured.

For animals Topical/otic — verify tympanic membrane integrity before otic use. Systemic oral use (GI decontamination): minimal absorption in normal GI tract but significant absorption in inflamed/damaged GI — nephrotoxicity risk. Contact allergy can develop with prolonged topical use. Not approved for use in food-producing animals. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Aminoglycoside — neomycin is one of the most common causes of contact allergy. Wear gloves when applying topical products. Avoid ear exposure. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention.

Contact your veterinarian. Oral neomycin overdose causes GI signs. Systemic toxicity possible if GI mucosal integrity is compromised.