Neostig Meth Inj 10/10ml

Anticholinesterase (neostigmine methylsulfate) for treatment of large colon impaction and post-operative GI ileus in horses; reversal of non-depolarizing neuromuscular blockade. Reversible anticholinesterase (neostigmine methylsulfate injectable). Mechanism: inhibits acetylcholinesterase → prevents ACh hydrolysis → increased ACh at NMJ (reverses non-depolarizing NMB) and smooth muscle M3 receptors (increased GI motility for impaction colic). Quaternary ammonium — poor CNS penetration. Key information Neostigmine — see neostigmine entry. Anticholinesterase. Have atropine available as antidote.

SQ injection only — do not give IV (too rapid onset, severe toxicity). Inject SQ into appropriate site. Atropine antidote must be available. Onset: 10–30 min. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Cholinergic excess: excessive salivation, lacrimation, urination, defecation, bradycardia, bronchospasm, muscle fasciculations, abdominal cramping (SLUDGE signs). Overdose: cholinergic crisis. Colic worsening if mechanical obstruction present in horses. Contraindicated with GI obstruction.

For animals CONTRAINDICATED in patients with GI or urinary obstruction — will worsen obstruction. Avoid in patients with bronchospasm. For colic in horses: rule out mechanical obstruction before use; have atropine available as antidote. Monitor closely for 30 min after administration. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Anticholinesterase — avoid skin contact. If accidentally injected, seek emergency medical attention (cholinergic crisis). Keep out of reach of children. Atropine is the antidote.

Contact your veterinarian. Neostigmine overdose causes cholinergic crisis. Antidote: atropine by veterinary staff.