Neupogen Inj 300/0.5

G-CSF (filgrastim) for treatment of neutropenia in dogs and cats; stimulates bone marrow neutrophil production. Recombinant human G-CSF (filgrastim). Mechanism: binds G-CSF receptors on neutrophil precursors and mature neutrophils → stimulates granulopoiesis, accelerates neutrophil production, and prolongs neutrophil survival. Increases circulating neutrophil count within 24 hrs of administration. SQ or IV injection. Key information Filgrastim — G-CSF. Refrigerate; do not freeze or shake. Subcutaneous or IV. Monitor CBC. Used for neutropenia in chemotherapy patients. Bone pain possible side effect.

SQ injection: administer SQ; may also give IV (dilute in D5W; infuse over 30 min). Rotate SQ injection sites. Store refrigerated (2–8°C); do not freeze. Bring to room temperature before use. Do not shake. Single-use vials. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Bone pain/discomfort (common — neutrophil expansion in bone marrow). Splenomegaly. Leukocytosis (expected). Rare: anaphylaxis. Splenic rupture (rare — humans; monitor). GI: nausea, vomiting (uncommon).

For animals Monitor CBC closely (leukocytosis expected; splenomegaly possible). Limited veterinary efficacy data — use for refractory neutropenia. Not approved for use in food-producing animals. For people handling this medication Administered by veterinary professionals only. No specific human precautions for caregivers beyond normal hygiene.

Contact your veterinarian. Filgrastim overdose causes severe bone pain, elevated white cell count, and rare spleen rupture. Managed by veterinary staff.