Nitrofurazone/dmso

General Drug Information and Indications

Compounded topical preparation of nitrofurazone in DMSO vehicle for enhanced penetration; treatment of infected wounds and soft tissue infections in horses. Compounded topical nitrofurazone in DMSO vehicle. Mechanism: nitrofuran antibacterial activity (reactive intermediate DNA/protein damage); DMSO penetration-enhancing solvent (carries drug across skin barrier) with additional anti-inflammatory and free-radical scavenging properties. Key information HUMAN SAFETY: Rapidly absorbed through skin — acts as carrier, pulling concurrent substances through skin. Wear chemical-resistant gloves. Avoid contact with skin. Strong carrier effect — remove all medications from hands before handling. Store at room temperature. May cause garlic breath/body odor.

How to Give this Medication

Topical wound preparation: apply to clean wound using sterile technique; dress appropriately. Do not apply to large open wounds (systemic absorption). Change dressing as directed. External use only. Store at room temperature; protect from light. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Side Effects

Strong garlic odor (DMSO). Local skin irritation, drying. DMSO: potentiates absorption of co-applied toxic substances. Nitrofurazone: contact sensitization. Avoid application to large open wounds.

Precautions

For animals Topical and wound use only — not for systemic administration. Not approved for use in food-producing animals. (potential carcinogen — no withdrawal time established). Avoid on large open wounds (systemic absorption). For people handling this medication f{GLOVES} DMSO vehicle significantly enhances skin penetration of nitrofurazone. Wear chemical-resistant gloves. Nitrofurazone is a potential carcinogen — avoid skin contact. {PREG} {WASH}

Overdose

Contact your veterinarian. DMSO is a carrier — overdose effects depend on co-administered drugs. DMSO itself causes garlic odor and mild local irritation. The real risk is from drugs dissolved in DMSO.

Nitrofurazone/dmso dosage forms

ProductStrengthFormSizeType
NITROFURAZONE/DMSO 0.13%/14.4% THROAT SPRAY (NO STEROID) - 1 PINT0.13%/14.4%Spray1 PINTCompound

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Compounding pharmacy formulation; Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)