General Drug Information and Indications

Procaine penicillin G injectable for susceptible bacterial infections in horses and cattle; streptococcal infections. Procaine penicillin G injectable (300,000 IU/mL). Mechanism: penicillinase-sensitive penicillin — binds PBPs → inhibits bacterial cell wall peptidoglycan synthesis (bactericidal). Procaine salt provides sustained absorption from IM site (12–24 hrs). Narrow spectrum: gram-positive cocci and rods; limited gram-negative coverage. Key information Procaine penicillin G injectable. Do NOT give IV — fatal CNS toxicity. IM injection only. Shake well. Refrigerate. Beef withdrawal: 10 days.

How to Give this Medication

IM ONLY — never administer IV (procaine toxicity). Shake well before each use. vigorously before drawing up. Inject deep IM into large muscle mass. Maximum volume per site: 10 mL (large animals); 2–3 mL (small animals). Administer q24h. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Side Effects

Hypersensitivity reactions: urticaria, pruritus, angioedema, anaphylaxis. Procaine toxicity (inadvertent IV injection): CNS toxicity, cardiovascular collapse — IM only. GI: diarrhea (uncommon). Injection site reactions (IM — pain, swelling). Superinfection.

Precautions

For animals IM ONLY — never administer IV (procaine toxicity → CNS and cardiovascular collapse). Avoid in penicillin-hypersensitive animals. Confirm susceptibility. Observe food animal withdrawal times for milk and meat. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Procaine penicillin injectable — penicillin allergy risk. Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately. Inform doctor if penicillin-allergic.

Overdose

Contact your veterinarian. Procaine penicillin overdose causes neurological signs (Hoigne's syndrome with procaine component). Emergency management required.

Norocillin 300 dosage forms

ProductStrengthFormSizeType
NOROCILLIN 250 ML 300,000 UNITS/ML INJ SUSP: PENICILLIN G PROCAINE—Injectable1Commercial
NOROCILLIN 300,000 UNITS/ML———Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual – Penicillins Use in Animals (https://www.merckvetmanual.com/pharmacology/antibacterial-agents/use-of-penicillins-in-animals); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)