General Drug Information and Indications

Robenacoxib (COX-2 selective NSAID) for post-operative pain and acute musculoskeletal pain in cats and dogs. COX-2 selective NSAID (robenacoxib). Mechanism: highly selective COX-2 inhibitor with rapid tissue uptake and long tissue half-life despite short plasma half-life → sustained effect at site of inflammation with reduced systemic exposure. Anti-inflammatory and analgesic. Licensed for dogs and cats. Short-term (≤3 days) perioperative or acute pain management. Key information Robenacoxib — COX-2 selective NSAID. Cats: injectable or tablet, short-term use (≤3 days tablets). Dogs: tablets. Administer with food (dogs). Do not use with other NSAIDs/corticosteroids.

How to Give this Medication

Oral tablets (dogs and cats): Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Administer once daily. Injectable (SQ, cats): administer SQ; limit to labeled duration. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

Side Effects

GI: vomiting, diarrhea, anorexia (COX-2 selective — lower GI risk than non-selective NSAIDs but still present). Renal toxicity with dehydration. Hepatotoxicity (rare). Do not use concurrently with other NSAIDs or corticosteroids. Cats: limited to short-term use (≤3 days).

Precautions

For animals Monitor for GI ulceration; use with caution in animals with GI disease. Monitor renal function, hydration status, and urine output. Cats: maximum 3 days use as labeled (perioperative/acute pain only) — prolonged use extra-label. Do not use concurrently with other NSAIDs or corticosteroids. Baseline blood work recommended. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). COX-2 NSAID — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.

Overdose

Contact your veterinarian immediately. NSAID overdose causes GI signs and kidney injury. Short-term product — contact vet before repeating any dose.

Onsior dosage forms

ProductStrengthFormSizeType
ONSIOR 20MG/ML INJECTION20 MG/MLInjectable1Commercial
ONSIOR TABS - 6MG - 30 TABS6 MGTablet1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual – Nonsteroidal Anti-inflammatory Drugs in Animals (https://www.merckvetmanual.com/pharmacology/inflammation/nonsteroidal-anti-inflammatory-drugs-in-animals); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)