Optimmune

Cyclosporine ophthalmic ointment (0.2%) for keratoconjunctivitis sicca (KCS/dry eye) and chronic superficial keratitis (pannus) in dogs. Cyclosporine ophthalmic ointment (0.2% cyclosporine in vehicle). Mechanism: cyclosporine binds cyclophilin → inhibits calcineurin → prevents NFAT nuclear translocation → suppresses IL-2 and other T-cell cytokines → reduces lymphocytic infiltration of lacrimal glands and cornea. Increases tear production in KCS. Local immunosuppression with minimal systemic absorption. Key information Cyclosporine 0.2% ophthalmic ointment. For ophthalmic use only. Do not touch tip to eye. Long-term use for KCS. Store at room temperature.

Ophthalmic ointment (cyclosporine 0.2%): apply a pea-sized ribbon (approximately 1 cm) to the lower conjunctival sac of each affected eye q12h. Can also apply to the inner aspect of the lower eyelid. Allow blinking to distribute. Wash hands before and after. Store at room temperature; protect from light. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Ophthalmic: mild transient burning/stinging (oil vehicle). Periocular hair coat changes (increased pigmentation, hypertrichosis — with periocular application). Blepharitis (rare). Systemic absorption: minimal from ophthalmic administration; systemic immunosuppression not expected.

For animals Twice-daily application required; clinical improvement may take 4–6 weeks. Do not use in patients with active ocular infection without concurrent antimicrobial therapy. Contraindicated in patients with active infectious keratitis. Lifelong therapy usually required for KCS. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Cyclosporine ophthalmic — immunosuppressant. Wear gloves when applying. Avoid contact with own eyes. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. Cyclosporine ophthalmic overdose is unlikely to cause systemic effects at this concentration.