Osphos 15ml

Clodronate (bisphosphonate) injectable for podotrochlear syndrome (navicular disease) and palmar foot pain in horses. Clodronate bisphosphonate (injectable). Mechanism: binds hydroxyapatite crystals in bone → internalized by osteoclasts → inhibits farnesyl pyrophosphate (FPP) synthase in mevalonate pathway → loss of osteoclast cytoskeletal function → reduced bone resorption. Also inhibits sensory nerve activity from bone (analgesic mechanism). Single IV injection for navicular syndrome. Key information Clodronate bisphosphonate for equine navicular disease. IV injection over 60 min — do not administer rapidly. Renal monitoring required. Single-use vial. Licensed for horses only.

IV infusion (horses): dilute in 250 mL 0.9% NaCl; infuse over 60 min via jugular catheter. Ensure horse is well hydrated before infusion. Single dose treatment — do not repeat for at least 6 months. Monitor for colic and GI adverse effects during and after infusion. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Injection site reactions (mild, transient). GI: colic, reflux, diarrhea (horses — transient, usually within first 24–48 hrs). Renal: azotemia (use with caution in dehydrated horses — ensure adequate hydration). Hypocalcemia (bisphosphonate — transient after IV infusion). Ataxia/neurological signs (rare). Uveitis (rare).

For animals Horses only. Ensure adequate hydration for 24 hrs before and after infusion. Monitor renal function, hydration status, and urine output. Monitor for colic and GI signs in first 24 hrs. Avoid concurrent nephrotoxic drugs. Do not repeat for at least 6 months. For people handling this medication Administered by veterinary professionals only. No specific human precautions for caregivers beyond normal hygiene.

Contact your veterinarian. Clodronate overdose causes hypocalcemia and kidney damage. Administered by veterinary staff.