Penicillin G Procaine Repack 300
General Drug Information and Indications
IM procaine penicillin G for susceptible bacterial infections in horses, cattle, and small animals; streptococcal infections and strangles.
Procaine penicillin G — narrow-spectrum IM penicillin. Mechanism: penicillin G inhibits PBPs → cell wall synthesis disruption (bactericidal). Procaine salt provides aqueous suspension for sustained IM absorption (12–24 hr duration). Local anesthetic effect from procaine component. Not for IV use.
Key information
Procaine penicillin G: do not inject IV — fatal CNS toxicity. IM injection only. Shake well. Penicillin allergy: cross-reactivity with cephalosporins possible. Refrigerate. Short withdrawal time required in food animals.
How to Give this Medication
IM ONLY — never administer IV (procaine causes fatal CNS/cardiovascular reactions). Shake well before each use. vigorously before drawing up (suspension). Inject deep IM into large muscle mass. Maximum injection volume per site. Administer q12–24h. Store at room temperature; protect from light.
If a dose is missed
Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Complete the full antibiotic course.
Side Effects
Hypersensitivity: urticaria, anaphylaxis. Procaine toxicity (inadvertent IV injection): CNS excitement, tremors, seizures, cardiovascular collapse — IM only. Injection site pain/swelling. GI: diarrhea (uncommon). Superinfection.
Precautions
For animals
IM ONLY — never IV (procaine toxicity → CNS collapse). Avoid in penicillin-hypersensitive animals. Observe food animal withdrawal times for milk and meat. Shake well before use.
For people handling this medication
Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Procaine penicillin — penicillin allergy risk; procaine toxicity if accidentally injected IV by handler. IM only. Wear gloves.
Overdose
Contact your veterinarian. Penicillin overdose rarely causes serious toxicity — GI signs are most common. High-dose IV potassium penicillin G overdose can cause fatal hyperkalemia.
Penicillin G Procaine Repack 300 dosage forms
| Product | Strength | Form | Size | Type |
|---|---|---|---|---|
| PENICILLIN G PROCAINE REPACK 300,000 UNITS/ML SUSPENSION - 250 ML | — | Suspension | 250 ML | Compound |
Sources
This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual – Penicillins Use in Animals (https://www.merckvetmanual.com/pharmacology/antibacterial-agents/use-of-penicillins-in-animals); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)