Penicillin/gentamicin 240

Combination bactericidal antibiotic (penicillin G + gentamicin) for treatment of mixed gram-positive/gram-negative bacterial infections in horses; synergistic spectrum coverage. Beta-lactam antibiotic (penicillin class). Mechanism: binds penicillin-binding proteins (PBPs) on bacterial cell wall → inhibits transpeptidation (peptidoglycan cross-linking) → weakened cell wall → osmotic lysis (bactericidal). Time-dependent killing; effective when drug concentration exceeds MIC for 40–70% of dosing interval. Key information Procaine penicillin G: do not inject IV — fatal CNS toxicity. IM injection only. Shake well. Penicillin allergy: cross-reactivity with cephalosporins possible. Refrigerate. Short withdrawal time required in food animals.

Injectable (procaine): Administer IM only — never IV. — never IV. Shake well before each use. before use. Deep IM injection. Oral (ampicillin, amoxicillin): Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Complete full course. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Complete the full antibiotic course.

Hypersensitivity reactions (urticaria, pruritus, angioedema, anaphylaxis — cross-reactive with cephalosporins ~5–10%). GI: diarrhea, vomiting (oral). Procaine component (procaine penicillin): CNS toxicity if given IV. Superinfection with resistant organisms. Small herbivores (rabbits, guinea pigs, hamsters): fatal enterocolitis.

For animals Avoid in beta-lactam-hypersensitive animals. CONTRAINDICATED in small herbivores (rabbits, guinea pigs, hamsters, gerbils) — fatal enterocolitis. Observe food animal withdrawal times for milk and meat. for food animals. Time-dependent killing. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Penicillin-class antibiotic — inform your doctor if you have penicillin allergy (serious anaphylaxis risk). Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately. Wear gloves.

Contact your veterinarian. Penicillin overdose rarely causes serious toxicity — GI signs are most common. High-dose IV potassium penicillin G overdose can cause fatal hyperkalemia.