Piroxicam

NSAID with antitumor properties for transitional cell carcinoma of the bladder, squamous cell carcinoma, and inflammatory conditions in dogs. Oxicam NSAID with antineoplastic properties (piroxicam). Mechanism: COX-1 and COX-2 inhibitor → reduced prostaglandins; antineoplastic effects may involve reduced PGE2-mediated immune suppression, induction of apoptosis in tumor cells, and inhibition of angiogenesis. Active against transitional cell carcinoma in dogs via COX-2 dependent and independent mechanisms. Key information NSAID with antitumor effects. DO NOT use in cats. Dogs only. Administer with food. Monitor renal function and GI. Used adjunctively for transitional cell carcinoma.

Oral capsules or tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. to minimize GI irritation. Administer once daily. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

GI: vomiting, diarrhea, gastric ulceration (COX-1 non-selective). Renal toxicity. Hepatotoxicity. Protein-losing enteropathy (dogs). Hematologic: platelet inhibition. Do not use with other NSAIDs or corticosteroids.

For animals Monitor for GI ulceration; use with caution in animals with GI disease. Monitor renal function, hydration status, and urine output. Do not use concurrently with other NSAIDs or corticosteroids. Monitor liver enzymes with prolonged use. Drug interaction: probenecid increases piroxicam levels. Antineoplastic use: monitor tumor response and dog tolerance. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). NSAID — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian immediately. Overdose causes GI ulceration and kidney injury. Supportive care required. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.