Polymyxin B Inj 500000

Last-resort antibiotic for multidrug-resistant gram-negative infections; low-dose IV in horses for endotoxin binding in endotoxemia; intrauterine infusion for equine endometritis. Polypeptide antibiotic (polymyxin B sulfate). Mechanism: cationic amphipathic cyclic peptide that binds to lipopolysaccharide (LPS) and phospholipids of gram-negative outer cell membrane → membrane disruption → cell death. Sub-antimicrobial doses bind and neutralize circulating endotoxin in horses. Nephrotoxic at antimicrobial doses. Key information Broad-spectrum antibiotic — gram-negative including Pseudomonas. Nephrotoxic with systemic use. IV: dilute; infuse slowly. For intrauterine/topical use in equine practice. Monitor renal function if systemic.

Topical/otic: apply as directed. Verify TM integrity before otic use. IV (endotoxemia, equine — sub-antimicrobial dose): dilute in 0.9% NaCl; infuse slowly over 1–2 hrs. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Nephrotoxicity and neurotoxicity (dose-dependent; systemic use — rare in veterinary sub-antimicrobial/endotoxin doses). Topical otic: ototoxicity if TM perforated. Pain at injection site. Histamine release (IV rapid infusion). Use with caution in renal impairment.

For animals Ototoxic with ruptured tympanic membrane — verify integrity before otic use. Systemic: nephrotoxic and neurotoxic at antimicrobial doses — not typically used systemically in horses (sub-antimicrobial endotoxin-binding dose is the common use). Monitor renal function, hydration status, and urine output. if used systemically. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Polypeptide antibiotic — avoid skin and eye contact with injectable form. Otic use: avoid ear exposure. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention.

Contact your veterinarian immediately. Polymyxin B overdose causes severe kidney damage and neuromuscular blockade. Medical emergency — supportive care required.