Ponazuril

Anticoccidial triazinetrione for EPM caused by Sarcocystis neurona in horses; coccidiosis in foals and small animals. Triazinetrione antiprotozoal (ponazuril). Mechanism: targets apicomplexan apicoplast organelle → disrupts folic acid metabolism, DNA replication, and organelle division in Sarcocystis neurona and Eimeria. Active against mature sarcocysts. Approved for EPM treatment in horses (Marquis). Also used for foal coccidiosis. Key information See Marquis entry. Antiprotozoal (EPM). 28-day course. Store at room temperature.

Oral paste: administer via dose syringe into the back of the mouth. Once daily for 28 days. Daily administration at the same time is important for consistent drug levels. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Continue the full 28-day course.

Generally very well tolerated at labeled doses in horses. GI: mild, transient loose feces. Behavioral changes (mild lethargy). No significant systemic toxicity documented at therapeutic doses.

For animals Complete full treatment course. Not approved for use in food-producing animals. Use with caution in pregnant animals. (limited safety data in pregnant mares — use cautiously). For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Antiprotozoal — Wash hands thoroughly with soap and water after handling. after handling paste. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. Ponazuril overdose is generally mild — GI signs most likely. Contact vet for guidance.