Prednisone Tab

Glucocorticoid prodrug for anti-inflammatory and immunosuppressive therapy in dogs; immune-mediated diseases, lymphoma, and allergic conditions. Glucocorticoid prodrug (prednisone). Mechanism: hepatically converted to active prednisolone → glucocorticoid receptor agonist → anti-inflammatory and immunosuppressive via phospholipase A2 inhibition and cytokine transcription suppression. Cats have limited hepatic conversion — use prednisolone instead. 4× potency of cortisol; mild mineralocorticoid activity. Key information Glucocorticoid. Immunosuppressive doses increase infection risk. Taper on discontinuation (>2 weeks of treatment). Monitor for PU/PD, GI ulceration, diabetes. Cats: prednisolone preferred (better hepatic conversion). Competition withdrawal required.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Tablets may be crushed. Administer in the morning. Taper dose gradually on discontinuation after prolonged use. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose.

Same as prednisolone. Additionally: cats have poor hepatic conversion from prednisone → prednisolone — use prednisolone in cats. PU/PD/PP, immunosuppression, muscle wasting, GI ulceration, laminitis (horses), HPA suppression, behavioral changes.

For animals Monitor for GI ulceration; use with caution in animals with GI disease. Avoid in pregnant animals. Laminitis risk in horses. Do not use concurrently with other NSAIDs or corticosteroids. Avoid live vaccines. Taper gradually after prolonged use. Cats: use prednisolone instead — poor hepatic conversion from prednisone in cats. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Corticosteroid — avoid prolonged skin contact. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Wear gloves when handling.

Contact your veterinarian. A single extra dose is unlikely to cause an emergency, but chronic overdose leads to Cushing's-like signs (PU/PD, pot belly, muscle wasting). Contact your vet and do not double future doses.