Probenecid Tab

Uricosuric agent for hyperuricemia; enhances antibiotic (beta-lactam) tissue levels by blocking tubular secretion. Uricosuric agent / renal organic anion transporter inhibitor (probenecid). Mechanism: competitively inhibits OAT1/OAT3 (organic anion transporters) in renal proximal tubule → blocks tubular secretion of uric acid → increases uric acid excretion (uricosuric). Also inhibits renal excretion of beta-lactam antibiotics and other organic anions → increases serum antibiotic levels. Key information Uricosuric agent — blocks renal tubular secretion of some antibiotics. Increases penicillin and ciprofloxacin levels. Store at room temperature. Administer with food.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. to reduce GI effects. Ensure adequate water intake. Administer consistently. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

GI: nausea, vomiting, anorexia, abdominal pain. Urolithiasis (uric acid stones in susceptible animals — Dalmatians). Renal: worsening of existing renal impairment. Hypersensitivity. Drug interactions: blocks elimination of multiple drugs (penicillins, cephalosporins, NSAIDs, methotrexate).

For animals Reduce dose or extend interval in renal impairment. Avoid in patients with history of urolithiasis. Drug interaction: inhibits renal secretion of penicillins, cephalosporins, NSAIDs, methotrexate (increases their levels — intended or adverse). For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Uricosuric agent — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.

Contact your veterinarian. Probenecid overdose causes GI signs, seizures, and kidney effects at high doses.