Progesterone/estradiol

Combination reproductive hormone therapy for estrus synchronization and uterine priming in mares; progesterone maintains uterine quiescence and estradiol induces receptivity and LH release. Combination sex hormone therapy: progesterone (P4) — progesterone receptor agonist → uterine quiescence, endometrial secretory transformation; estradiol (E2) — estrogen receptor agonist → stimulates LH surge and uterine receptivity. Combined for estrus synchronization, uterine priming, and embryo transfer preparation in mares. Key information HUMAN SAFETY: Wear gloves — dermal absorption. Refrigerate injectable solutions. Used for luteal supplementation and maintenance of early pregnancy in mares. Monitor progesterone levels to confirm therapeutic range.

Injectable (oil-based): warm vial to room temperature; administer IM into large muscle mass. Oral (compounded): Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Topical (compounded cream): apply to mucous membranes or as directed using gloves. Store at room temperature; protect from light. If a dose is missed This product is given as a single dose or as part of a defined protocol. Contact your veterinarian if a scheduled administration was missed. Contact your veterinarian for guidance on reproductive timing.

Pyometra/endometrial hyperplasia (intact females). Myelosuppression (estradiol component — monitor CBC). Masculinization of female fetuses. Behavioral changes. Weight gain. Mammary abnormalities. Human skin contact hazard (especially pregnant women).

For animals Intact females: risk of pyometra and endometrial hyperplasia. Stallion-exposed mares: behavioral effects. Monitor for signs of adverse reactions. Not approved for use in food-producing animals. (most formulations). For people handling this medication Wear gloves when handling. Combination sex hormones — wear gloves at all times. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Both hormones can be absorbed dermally and cause hormonal effects. Women of childbearing age should use extra precautions.

Contact your veterinarian. Progesterone overdose causes prolonged progestogenic effects and may affect reproductive outcomes.