Proin Er

Phenylpropanolamine (PPA) for urethral sphincter mechanism incompetence (urinary incontinence) in spayed female dogs. Sympathomimetic urologic agent (phenylpropanolamine HCl). Mechanism: indirect-acting sympathomimetic — releases stored norepinephrine and has weak direct alpha/beta adrenergic agonist activity → stimulates alpha-1 receptors in urethral sphincter → increased urethral closure pressure → reduced urinary incontinence. Oral tablets. FDA-approved for dogs. Key information Phenylpropanolamine (PPA) — urethral sphincter tone agent. For urinary incontinence in dogs. Store at room temperature. Monitor blood pressure — hypertension risk. Do not use in dogs with hypertension, heart or kidney disease.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Administer 2–3 times daily as directed. Extended-release tablets: administer once daily with food — do not crush. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

Cardiovascular: hypertension, tachycardia, palpitations (most important concern — monitor BP). GI: anorexia, vomiting. CNS: restlessness, excitability, anxiety. Urinary: stranguria (paradoxical urethral spasm at high doses). Contraindicated with hypertension, glaucoma, cardiac disease.

For animals Contraindicated in patients with hypertension, glaucoma, hypothyroidism, or concurrent sympathomimetic therapy. Monitor blood pressure before initiating and periodically during therapy. Not approved for use in food-producing animals. Avoid in pregnant animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Sympathomimetic — Wash hands thoroughly with soap and water after handling. after handling. May cause hypertension if accidentally ingested. Keep out of reach of children.

Contact your veterinarian. Phenylpropanolamine overdose causes high blood pressure, rapid heart rate, anxiety, and tremors. Emergency blood pressure monitoring required. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.