Prozinc

Protamine zinc insulin for long-term glycemic management of diabetes mellitus in cats. Protamine zinc insulin — ultra-long-acting porcine insulin. Mechanism: protamine and zinc complex slows insulin absorption from SQ site → once or twice daily dosing for cats. Binds insulin receptors → promotes glucose uptake by muscle and adipose; suppresses hepatic glucose output. FDA-approved for feline and canine diabetes mellitus. Key information Protamine zinc insulin (PZI) for cats and dogs. Refrigerate; discard 60 days after first use. Roll gently (do not shake). Subcutaneous injection. Monitor blood glucose 1–2 hours after injection. Do not mix with other insulins.

SQ injection only: gently roll vial to resuspend (milky suspension) — do not shake vigorously. Administer SQ into dorsal neck or scruff. Administer once or twice daily at consistent times relative to feeding. Store refrigerated (2–8°C); do not freeze. (shake gently before each use); do not freeze. If a dose is missed If a dose is missed, check blood glucose if possible and contact your veterinarian before giving another dose. Do not double up.

Hypoglycemia (most important): weakness, ataxia, tremors, seizures, coma. Lipodystrophy at injection sites. Local injection site reactions. Hypokalemia. Weight gain. Cats: Somogyi effect (rebound hyperglycemia after hypoglycemia).

For animals Monitor blood glucose curves (12 hr post-injection). Adjust dose based on glucose nadir. Avoid concurrent corticosteroids (insulin antagonists). Somogyi effect (rebound hyperglycemia) can mimic inadequate control — check glucose curve. For people handling this medication Wear gloves when handling. Insulin — if accidentally self-injected, consume sugar immediately and seek emergency medical attention. Keep out of reach of children. Refrigerate.

This is a veterinary emergency. Insulin overdose causes hypoglycemia — tremors, seizures, and collapse. Rub corn syrup on the gums immediately and go to an emergency animal hospital.