Pyrantel Pamoate

Anthelmintic (pyrantel pamoate) for intestinal nematodes (strongyles, roundworms, pinworms) in horses, dogs, and cats. Pyrimidine anthelmintic (pyrantel pamoate). Mechanism: nicotinic acetylcholine receptor (nAChR) agonist → sustained depolarizing neuromuscular blockade (spastic paralysis) in nematodes → paralyzed worms expelled by gut motility. Active against luminal stages of strongyles (not encysted small strongyles), ascarids, and pinworms in horses. Not absorbed — local GI action. Key information Anthelmintic — roundworms, hookworms. Store at room temperature. Safe in pregnancy. Administer with or without food. Monthly dosing for prevention.

Oral paste (horses): administer via dose syringe at the correct weight marking. Oral suspension (small animals): measure carefully; Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Shake well before each use. (suspension). Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

GI: mild vomiting, diarrhea, anorexia (uncommon). Salivation. Generally very well tolerated — poorly absorbed. CNS toxicity at very high overdose (rare). Hepatotoxicity (rare).

For animals Luminal activity only — not effective against encysted small strongyle larvae. Resistance monitoring recommended (fecal egg count reduction test). Safe in pregnant mares. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Anthelmintic — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.

Contact your veterinarian. Pyrantel overdose causes GI signs (vomiting, diarrhea). Rarely serious at moderate overdoses.