R-gel 4ml Liquid: Amikacin/clindamycin

Compounded ophthalmic gel combining amikacin (aminoglycoside) and clindamycin for treatment of serious ocular infections including bacterial keratitis and corneal ulcers in horses. Lincosamide antibiotic. Mechanism: binds 50S ribosomal subunit → inhibits bacterial protein synthesis. Excellent gram-positive, anaerobic, and intracellular coverage (Toxoplasma). Good bone penetration. Avoid in rabbits and small herbivores (fatal colitis). Partially hepatically metabolized. Key information Do NOT use in rabbits, guinea pigs, hamsters, or other hindgut fermenters — fatal pseudomembranous colitis. Use with caution in horses — rarely used due to dysbiosis risk. Store at room temperature.

Oral capsules/tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. and follow with water (esophageal irritation risk). Compounded oral liquid: Shake well before each use. Store refrigerated (2–8°C); do not freeze. Injectable: IV (dilute; infuse over 30–60 min) or IM. Topical: apply thin layer. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

GI: diarrhea, vomiting, esophageal stricture (oral capsules — give with water and remain upright). Antibiotic-associated colitis. CONTRAINDICATED in horses, rabbits, guinea pigs, hamsters, ruminants (fatal colitis). Rare: hepatotoxicity.

For animals CONTRAINDICATED in horses, rabbits, guinea pigs, hamsters, gerbils, and ruminants — fatal Clostridium-associated enterocolitis. Monitor for diarrhea in dogs and cats; discontinue if severe. Use with caution in hepatic impairment. Reduce dose or extend interval in renal impairment. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Lincosamide — Wash hands thoroughly with soap and water after handling. after handling. Risk of antibiotic-associated diarrhea if swallowed.

Contact your veterinarian. Amikacin/clindamycin intrauterine gel — contact vet if dosing error occurred.