Reconcile (fluoxetine)

Fluoxetine (SSRI) FDA-approved for canine separation anxiety in conjunction with behavior modification. SSRI (fluoxetine HCl) — FDA-approved for canine separation anxiety. Mechanism: selective serotonin reuptake inhibitor → blocks SERT → increases synaptic serotonin levels → behavioral effects via multiple 5-HT receptor subtypes. Behavioral effects take 3–4 weeks. Active metabolite norfluoxetine. Used in conjunction with behavioral modification program. Key information Fluoxetine chewable tablet for dogs. See fluoxetine entry. Dogs only. Allow 4–6 weeks for full effect. Do not combine with MAOIs.

Oral chewable tablet: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Once daily. Use as part of a concurrent behavioral modification program. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose. Allow 4–6 weeks for full effect.

GI: decreased appetite, vomiting, diarrhea (common initially). CNS: sedation or insomnia, agitation. Serotonin syndrome with MAOIs. Behavioral: paradoxical aggression (rare). Slow taper to discontinue.

For animals FDA-approved for dogs only (separation anxiety). Allow 14-day washout from MAOIs. Use in conjunction with behavioral modification program. Behavioral effects require 3–4 weeks. Use with caution in pregnant animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). SSRI — Wash hands thoroughly with soap and water after handling. after handling. Keep away from children. Serotonin syndrome risk if ingested with human serotonergic drugs.

Contact your veterinarian immediately. Fluoxetine overdose causes serotonin syndrome (agitation, tremors, hyperthermia).