Regumate

Altrenogest (progesterone analogue) for suppression of estrus, pregnancy maintenance, and estrus synchronization in mares; FDA-approved equine product. Altrenogest 0.22% solution in oil (equine FDA-approved product). Mechanism: synthetic progestogen — progesterone receptor agonist → suppresses LH/FSH (anovulation), maintains uterine quiescence (pregnancy support), suppresses estrus behavior. DANGER: strong transdermal absorption in humans — causes menstrual irregularities and fetal abnormalities. Use chemical-resistant gloves. Key information Altrenogest — progestogen. EXTREME HUMAN SAFETY HAZARD: Dermally absorbed; causes prolonged luteal phase, menstrual disruption, and endocrine disruption in women. Wear chemical-resistant gloves (not latex). Avoid all skin contact. Pregnant women and women of childbearing age must NOT handle under any circumstances.

Oral administration (mares): administer via dose syringe into the mouth or mix into a small amount of grain. Wear chemical-resistant (nitrile) gloves throughout. Wash hands thoroughly after handling. Administer once daily at consistent time. Store at room temperature; protect from light. If a dose is missed This product is given as a single dose or as part of a defined protocol. Contact your veterinarian if a scheduled administration was missed. Part of a reproductive protocol — contact your veterinarian.

Behavioral changes (estrus suppression). Uterine fluid accumulation in infected mares. Human safety: significant transdermal absorption — endocrine disruption, menstrual effects, potential teratogenicity. Use chemical-resistant (NOT latex) gloves at all times.

For animals See altrenogest. Avoid in mares with active endometritis without concurrent antimicrobial therapy. Suppresses natural estrous cycle — plan discontinuation timing based on breeding goals. For people handling this medication DANGER: Altrenogest (Regumate) is readily absorbed through human skin and is a potent reproductive hazard. Pregnant women and women of childbearing age must NOT handle this product under any circumstances — can cause serious hormonal disruption and fetal harm. Wear chemical-resistant gloves (nitrile or neoprene — NEVER latex). Cover all exposed skin with protective clothing. If skin contact occurs, wash immediately and thoroughly with soap and water for at least 15 minutes and contact your physician. If eye contact occurs, flush with water for 15+ minutes and seek immediate medical attention. Contact Poison Control (1-800-222-1222) for any significant exposure. Keep out of reach of children.

Human or animal exposure to excess altrenogest requires immediate action. For the animal: contact your veterinarian. For human skin exposure: wash thoroughly with soap and water immediately and call Poison Control (800-222-1222).