Revolution Feline (blue) 5-15 Lb Liquid: Selamectin

Selamectin topical antiparasitic for fleas, heartworm, ear mites, and internal/external parasites in dogs and cats. Avermectin topical ectoparasiticide/anthelmintic (selamectin). Mechanism: potentiates glutamate-gated chloride channels (GluCl) specific to invertebrates → chloride influx → hyperpolarization → paralysis of fleas, heartworm microfilariae, ear mites, and nematodes. Monthly spot-on application. Also blocks filarial microfilariae development preventing adult heartworm development. Key information Selamectin — topical ectoparasiticide/heartworm prevention. For dogs and cats — use correct species-specific product. Apply to skin at back of neck. Allow to dry before handling. Monthly application. Do not use in kittens <8 weeks or puppies <6 weeks.

Topical spot-on: part the fur at the base of the neck (between shoulder blades for cats; just in front of the shoulder blades for dogs). Apply entire contents of tube to skin — not fur. Avoid contact with the application site until dry. Administer monthly. Store at room temperature; protect from light. If a dose is missed Apply the missed dose when remembered and resume monthly schedule.

Local: mild hair loss, white residue, temporary skin irritation at application site. Rare: hypersalivation (if licked — alcohol base). CNS toxicity in MDR1-mutant dogs (higher avermectin class sensitivity). Generally very well tolerated at labeled doses.

For animals Dogs with MDR1 mutation: selamectin at preventive doses generally safe. Cats: do not use canine formulation (different concentrations). Do not apply to broken skin. Not approved for use in food-producing animals. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Avoid inhaling sprays or aerosols. Keep out of reach of children. Spot-on antiparasitic — wear gloves when applying and do not allow treated area to be touched until dry. Wash hands thoroughly with soap and water after handling. Keep children away from treated animal until dry.

If excessive product was applied, wash the area thoroughly with mild soap and water. Contact your veterinarian if the animal shows any signs of irritation, lethargy, tremors, or other unusual behavior. Selamectin overdose may cause lethargy, salivation, and muscle tremors. Contact your veterinarian. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.