Riboflavin

Vitamin B2 supplementation for deficiency; ophthalmic use in corneal cross-linking for equine infectious keratitis. Vitamin B2 (riboflavin). Mechanism: water-soluble vitamin component of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) coenzymes → essential for oxidative phosphorylation, fatty acid oxidation, and electron transport. Ophthalmic use: riboflavin absorbs UV light (UVA, 370 nm) in corneal cross-linking procedures → photoactivation generates reactive oxygen species → collagen cross-linking. Key information Vitamin B2 supplement. Store at room temperature. Protect from light. Safe supplement — water-soluble. May turn urine yellow.

Ophthalmic cross-linking: apply per established corneal cross-linking protocol. IV/oral supplementation: as directed. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If you forget a day, simply resume the normal schedule the next day. Missing an occasional dose of this supplement is unlikely to cause harm.

Very safe (water-soluble). Yellow-green fluorescent urine (expected, harmless). Rare: hypersensitivity. Ophthalmic cross-linking: UV corneal epithelial damage if protocol not followed.

For animals Ophthalmic cross-linking: follow established UV protocol. Monitor corneal integrity. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Vitamin B2 — generally safe. Yellow urine (expected). Wash hands thoroughly with soap and water after handling.

Overdose with this supplement is unlikely to cause serious harm at slightly elevated doses, but contact your veterinarian if a large excess was given or if your animal shows any unusual signs. Riboflavin excess is excreted in urine (causes bright yellow coloration) — systemic toxicity is very low.