Rompun

Xylazine (alpha-2 agonist) for sedation, analgesia, and preanesthetic medication in horses, cattle, dogs, and cats. Alpha-2 adrenergic agonist (xylazine HCl). Mechanism: stimulates presynaptic and postsynaptic alpha-2A and alpha-2B receptors in the CNS → reduces norepinephrine release → dose-dependent sedation, analgesia, and muscle relaxation. Initial peripheral vasoconstriction followed by bradycardia and reduced cardiac output. Reversible with atipamezole (small animals) or yohimbine. Key information Xylazine — see xylazine entry. DEA Schedule III. Reversal: yohimbine. Cattle: 10x more sensitive than horses — reduce dose significantly.

IV or IM injection (horses, dogs, cats). IV (horses): administer slowly into jugular vein — full effect in 2–5 min. IM (horses): onset 10–20 min. Cattle: IM only at 1/10th equine dose. Dogs/cats: IM or SQ. Have reversal agent available. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Cardiovascular: bradycardia, AV block, initial peripheral vasoconstriction (hypertension), then peripheral vasodilation/hypotension. Respiratory: rate and tidal volume reduction; horses may obstruct upper airway (keep head elevated). GI: decreased motility, ileus, colic (horses). Diuresis. Sweating (horses). Cattle: highly sensitive — use 1/10th equine dose. Reversible with yohimbine (dogs/cats) or atipamezole.

For animals See xylazine. Cattle: 10× more sensitive than horses. No approved reversal in horses; yohimbine for dogs/cats. Monitor cardiac, respiratory, and GI function. Keep horse head elevated. Not approved for use in food-producing animals. For people handling this medication Wear gloves when handling. Alpha-2 agonist sedative — avoid skin contact and accidental injection. Even small accidental doses can cause dangerous sedation, bradycardia, and respiratory depression in humans. If accidentally self-injected, seek emergency medical attention immediately. Do not drive or operate machinery after handling. Keep out of reach of children.

Veterinary emergency — see xylazine. Reversal with yohimbine by veterinary staff required.