Saline, Hypertonic Liter Bottle

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General Drug Information and Indications

Hypertonic saline (7.2% or 7.5% NaCl) IV for emergency volume resuscitation and treatment of hyponatremia in horses and small animals; rapid osmotic fluid shift. Hypertonic saline solution (7.2% NaCl). Mechanism: extreme hyperosmolality → rapid osmotic draw of intracellular and interstitial fluid into vasculature → rapid plasma volume expansion (3–4× volume given); reduces cerebral edema (osmotic dehydration of brain cells); activates systemic immune response (immunostimulatory effect). Short-acting (30–60 min); must follow with isotonic fluids. Key information Hypertonic saline (7.2–7.5%). Administer 1–2 L IV over 15–20 min in horses — must be followed by isotonic crystalloids. Do NOT use repeatedly or in large volumes. Monitor serum sodium. Check concentration before use.

How to Give this Medication

IV via large-bore catheter (jugular preferred): administer slowly over 3–5 min. Follow immediately with 3–4× volume of isotonic crystalloids. Monitor closely during and after. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Side Effects

Severe phlebitis in small peripheral veins (use large-bore catheter/jugular). Rebound cerebral edema with rapid overcorrection of hyponatremia. Hypernatremia. Hemolysis with perivascular administration.

Precautions

For animals Use large-bore catheter/jugular vein. Follow immediately with isotonic crystalloids. Monitor sodium levels. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Hypertonic saline — administered by veterinary staff. Wash hands thoroughly with soap and water after handling.

Overdose

Contact your veterinarian. Hypertonic saline overdose causes severe hypernatremia, seizures, and cardiovascular compromise. Emergency IV fluid management required.

Saline, Hypertonic Liter Bottle dosage forms

ProductStrengthFormSizeType
SALINE, HYPERTONIC LITER BOTTLE 7.2% IV (Covetrus)——1Commercial
SALINE, HYPERTONIC LITER BOTTLE 7.2% IV (VetOne)——1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)