Sentinel Spectrum Canine 8.1-25lbs Tablet
General Drug Information and Indications
Combination anthelmintic/flea preventive (milbemycin/lufenuron/praziquantel) for heartworm, flea control, and intestinal parasites in dogs.
Combination preventive (milbemycin oxime + lufenuron + praziquantel). Milbemycin: macrocyclic lactone → GluCl channel potentiation → nematode/heartworm prevention; lufenuron: chitin synthesis inhibitor → prevents flea egg hatching (insect development inhibitor, no adult flea kill); praziquantel: tegument disruption → tapeworm killing.
Key information
Milbemycin/lufenuron/praziquantel — combination parasite prevention. Dogs only. Monthly administration. Administer with food for best absorption. Use caution in MDR1-mutation breeds.
How to Give this Medication
Oral chewable tablet: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Administer monthly. Use correct body weight product. Store at room temperature; protect from light.
If a dose is missed
Give the missed dose as soon as you remember and resume monthly administration. Always give with food.
Side Effects
GI: vomiting, diarrhea, lethargy (most common adverse effects). CNS: tremors, ataxia, seizures (rare — isoxazoline component). Generally well tolerated at monthly doses. Lufenuron component: no adult flea-killing effect (IDI only — larvicide).
Precautions
For animals
Use with caution in dogs with seizure history. Not for puppies <8 weeks. Not approved for use in food-producing animals.
For people handling this medication
Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Combination antiparasitic — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.
Overdose
Contact your veterinarian. Sentinel Spectrum overdose may cause GI signs and neurological effects (milbemycin component). Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.
Sentinel Spectrum Canine 8.1-25lbs Tablet dosage forms
| Product | Strength | Form | Size | Type |
|---|---|---|---|---|
| SENTINEL SPECTRUM CANINE 2-8LBS CHEWABLE TAB: MILBMYCIN OXIME/LUFENURON/PRAZIQUANTEL | — | Tablet | 1 | Commercial |
| SENTINEL SPECTRUM CANINE 25.1-50 LBS TABLET | — | Tablet | 1 | Commercial |
| SENTINEL SPECTRUM CANINE 50-100 LBS TABLET | — | Tablet | 1 | Commercial |
| SENTINEL SPECTRUM CANINE 8.1-25LBS TABLET | — | Tablet | 1 | Commercial |
Sources
This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)