Sertraline Hydrochloride

SSRI antidepressant for anxiety, separation anxiety, and stereotypic behaviors in dogs and cats. SSRI antidepressant/anxiolytic (sertraline HCl). Mechanism: selective serotonin reuptake inhibitor → blocks SERT → increases synaptic serotonin → behavioral effects via multiple 5-HT receptor subtypes (anxiolytic, mood stabilizing). Oral tablets. Hepatically metabolized via CYP2C19/2D6. Used for fear-based behaviors, OCD, and aggression in dogs and cats. Key information SSRI antidepressant. Allow 4–6 weeks for full effect. Do not combine with MAOIs. Serotonin syndrome risk with other serotonergic drugs. Taper on discontinuation. Store at room temperature.

Oral tablets or capsules: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Tablets may be crushed. Administer at consistent times. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose. Allow 4–6 weeks for full effect.

GI: decreased appetite, vomiting, diarrhea, weight loss (common — often transient). CNS: lethargy or agitation, anxiety, restlessness. Serotonin syndrome (with MAOIs or serotonergic drugs — potentially fatal — discontinue MAOIs 14 days before starting). Behavioral: paradoxical aggression (rare). Discontinue slowly to avoid withdrawal.

For animals Allow 14-day washout from MAOIs. Avoid concurrent tramadol, trazodone, and other serotonergic drugs. Gradual taper on discontinuation. Monitor liver enzymes with prolonged use. Not approved for use in food-producing animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). SSRI — Wash hands thoroughly with soap and water after handling. after handling. Keep away from children. Serotonin syndrome risk if ingested.

Contact your veterinarian immediately. SSRI overdose causes serotonin syndrome: agitation, tremors, hyperthermia, and seizures. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.