Silvadene Cream

Silver sulfadiazine cream for burns and infected wounds in horses and small animals; broad-spectrum antimicrobial. Silver sulfadiazine 1% topical cream. Mechanism: silver ions (Ag+) disrupt microbial DNA replication and cell membrane function (bactericidal/fungicidal); sulfadiazine provides additional sulfonamide antibacterial activity. Broad-spectrum topical antimicrobial. Maintains moist wound environment. Standard of care for burns in veterinary medicine. Key information Silver sulfadiazine cream. See silver sulfadiazine entry. Do not use on large burns in cats. Wear gloves.

Topical cream: apply 2–4 mm layer to wound surface using gloved applicator or sterile tongue depressor. Cover with non-adherent dressing. Change dressing daily or as needed. Store at room temperature; protect from light. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Local: burning, pain upon application. Skin: leukopenia (transient sulfonamide effect with large-area application). Sulfonamide hypersensitivity. Argyria (silver deposition — rare with prolonged large-area use). Impaired escharotomy if thick eschar present.

For animals Sulfonamide derivative — avoid in sulfonamide-hypersensitive patients. Not for use in neonates (sulfonamides displace bilirubin). Monitor leukocyte count with large-area application. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Silver sulfadiazine cream — wear gloves when applying. Sulfonamide allergy risk. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention.

If excessive product was applied, wash the area thoroughly with mild soap and water. Contact your veterinarian if the animal shows any signs of irritation, lethargy, tremors, or other unusual behavior. Contact your veterinarian. Excessive application on large areas may cause sulfonamide absorption, especially in cats.