General Drug Information and Indications

Silver sulfadiazine topical cream for treatment of burns, infected wounds, and antimicrobial prophylaxis in horses and small animals. Silver sulfadiazine topical cream 1%. Mechanism: silver (Ag+) ions disrupt microbial DNA synthesis and cell membrane function; sulfadiazine provides sulfonamide antimicrobial activity. Together: broad-spectrum antibacterial and antifungal for burn/wound management. Key information Silver sulfadiazine — topical antimicrobial. External use only. See silver sulfadiazine entry.

How to Give this Medication

Topical cream: apply with gloved hands or sterile applicator to wound. Cover with non-adherent dressing. Change daily. Store at room temperature; protect from light. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Side Effects

Same as silvadene. Transient leukopenia (large-area application). Sulfonamide hypersensitivity. Local burning on application. Argyria (very rare).

Precautions

For animals See silvadene. Sulfonamide hypersensitivity. Monitor WBC with large-area use. Avoid in neonates. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Silver sulfonamide — wear gloves. Sulfonamide allergy risk. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention.

Overdose

If excessive product was applied, wash the area thoroughly with mild soap and water. Contact your veterinarian if the animal shows any signs of irritation, lethargy, tremors, or other unusual behavior. Contact your veterinarian. Large area application may cause systemic sulfonamide effects.

Silver Sulfa Cre dosage forms

ProductStrengthFormSizeType
SILVER SULFA CRE 1% REAM———Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)