Smz/tmp Ds Tab 800-160

Trimethoprim-sulfamethoxazole (TMS/SMZ) combination antibiotic for susceptible bacterial infections in horses, dogs, and cats; respiratory, urinary, and soft tissue infections. Potentiated sulfonamide antibiotic combination (trimethoprim-sulfamethoxazole or trimethoprim-sulfadiazine). Mechanism: sulfamethoxazole/sulfadiazine inhibits dihydropteroate synthase (PABA competitive antagonist); trimethoprim inhibits dihydrofolate reductase → synergistic sequential blockade of folate synthesis pathway → bactericidal at combination concentrations. Key information Sulfamethoxazole/trimethoprim — see SMZ-TMP entry. Ensure adequate water intake. Loading dose recommended. Monitor CBC.

Oral powder (horses): mix into grain. Tablets (small animals): Administer with food to reduce GI adverse effects. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Always ensure adequate water intake. Complete the full course.

GI: anorexia, vomiting, diarrhea. Renal: crystalluria, urolithiasis (adequate hydration required). Hematologic: bone marrow suppression (CBC monitoring with prolonged use). KCS (dry eye) in dogs — one of most common adverse effects with chronic use. Hepatotoxicity (rare). Hypersensitivity (fever, skin rash). Folate depletion.

For animals Adequate hydration essential (crystalluria). Reduce dose or extend interval in renal impairment. Monitor CBC periodically with prolonged use. Dogs: KCS monitoring with chronic use. Monitor liver enzymes with prolonged use. Use with caution in pregnant animals. Avoid in patients with sulfonamide hypersensitivity. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Potentiated sulfonamide — inform doctor if sulfa-allergic. Wash hands thoroughly with soap and water after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. SMZ-TMP overdose causes GI signs, crystalluria (kidney), and bone marrow suppression. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.